TCM, brain function and drug space

Nat Prod Rep. 2016 Jan;33(1):6-25. doi: 10.1039/c5np00049a.


Covering: up to 2015. Traditional Chinese medicine has played a significant role in the mainstream healthcare system in China for thousands of years. Here, we summarize 84 major compounds from 15 selected herbal medicines targeting neurodegenerative diseases. We present a perspective based on the analysis of physicochemical properties of these TCM compounds, and comparison with current drugs and candidates for the treatment of Parkinson's and Alzheimer's disease. The results demonstrate that traditional Chinese medicines contain compounds possessing physicochemical properties that have excellent overlap with developed western medicines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Brain / physiopathology*
  • Humans
  • Medicine, Chinese Traditional*
  • Molecular Structure
  • Parkinson Disease / drug therapy
  • Plants, Medicinal / chemistry*