Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update

J Orthop Trauma. 2015 Dec;29 Suppl 12:S6-9. doi: 10.1097/BOT.0000000000000465.


Fracture healing is a unique multifaceted process requiring the presence of cells, molecular mediators, and angiogenic factors. The state of inflammation dominates the initial phase, but the ideal magnitude and duration of the process for an optimal outcome remains obscure. Biological response modifiers, such as platelet-rich plasma (PRP) preparations, have been used to reconstitute the desirable early inflammatory state, but the results obtained remain inconclusive. Ongoing research to characterize and quantify the inflammatory response after bone fracture is essential in order to better understand the molecular insights of this localized reaction and to expand our armamentarium in the management of patients with an impaired fracture healing response. Non-steroidal anti-inflammatory drugs frequently administered for analgesia after trauma procedures continue to be a cause of concern for a successful bone repair response.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / administration & dosage*
  • Bone Regeneration / drug effects
  • Bone Regeneration / immunology*
  • Bone and Bones / drug effects
  • Bone and Bones / immunology*
  • Evidence-Based Medicine
  • Fracture Healing / drug effects
  • Fracture Healing / immunology*
  • Humans
  • Models, Immunological
  • Osteitis / drug therapy*
  • Osteitis / immunology*
  • Treatment Outcome


  • Anti-Inflammatory Agents