Epidemic myalgia and myositis associated with human parechovirus type 3 infections occur not only in adults but also in children: findings in Yamagata, Japan, 2014

Epidemiol Infect. 2016 Apr;144(6):1286-90. doi: 10.1017/S0950268815002873. Epub 2015 Nov 20.


We previously reported an association between human parechovirus type 3 (HPeV3) and epidemic myalgia with myositis in adults during summers in which an HPeV3 outbreak occurred in children. However, this disease association has not yet been reported elsewhere. We have since continued our surveillance to accumulate data on this disease association and to confirm whether myalgia occurs in children as well as adults. Between June and August 2014, we collected 380 specimens from children with infectious diseases. We also collected clinical specimens from two adult and three paediatric patients suspected of myalgia. We then performed virus isolation and reverse-transcription-PCR using the collected specimens. We detected HPeV3 in 26 children with infectious diseases, which we regarded as indicating an outbreak. We also confirmed HPeV3 infection in all patients suspected of myalgia. In particular the symptoms in two boys, complaining of myalgia and fever, closely matched the criteria for adult myalgia. Based on our findings from 2008, 2011 and 2014, we again urge that clinical consideration be given to the relationship between myalgia and HPeV3 infections during HPeV3 outbreaks in children. Furthermore, our observations from 2014 suggest that epidemic myalgia and myositis occur not only in adults but also in children.

Keywords: Adult; HPeV3; child; myalgia; myositis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Japan / epidemiology
  • Male
  • Myositis / epidemiology*
  • Myositis / etiology*
  • Myositis / virology
  • Parechovirus / isolation & purification*
  • Picornaviridae Infections / complications*
  • Picornaviridae Infections / epidemiology*
  • Picornaviridae Infections / virology
  • Pleurodynia, Epidemic / epidemiology*
  • Pleurodynia, Epidemic / etiology*
  • Pleurodynia, Epidemic / virology
  • Reverse Transcriptase Polymerase Chain Reaction