Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis

Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1436-46. doi: 10.1016/j.bbamcr.2015.11.008. Epub 2015 Nov 14.


Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes, including proliferation, cell migration and cell survival. As a consequence, members of this ion family play prominent roles during embryonic development, tissue maintenance and cancer progression. Although most TRP channels are non-selective, many cellular responses, mediated by TRP channels, appear to be calcium-dependent. In addition, there is mounting evidence for channel-independent roles for TRP channels. In this review, we will discuss how both these channel-dependent and -independent mechanisms affect cellular programs essential during embryonic development, and how perturbations in these pathways contribute to a variety of pathologies. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.

Keywords: Calcium; Embryonic development; Epithelial-mesenchymal transition (EMT); TRP channels; Tissue homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcium / metabolism*
  • Cytoskeleton / metabolism
  • Embryonic Development / genetics
  • Embryonic Development / physiology*
  • Gene Expression Regulation
  • Homeostasis / genetics
  • Homeostasis / physiology*
  • Humans
  • Models, Biological
  • Multigene Family
  • Organ Specificity
  • Transient Receptor Potential Channels / genetics
  • Transient Receptor Potential Channels / metabolism*


  • Transient Receptor Potential Channels
  • Calcium