Quizartinib elicits differential responses that correlate with karyotype and genotype of the leukemic clone

Leukemia. 2016 Jun;30(6):1422-5. doi: 10.1038/leu.2015.320. Epub 2015 Nov 20.
No abstract available

Publication types

  • Clinical Trial, Phase II
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzothiazoles / pharmacology
  • Benzothiazoles / therapeutic use*
  • Genotype*
  • Humans
  • Karyotyping*
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / genetics
  • Mutation
  • Phenylurea Compounds / pharmacology
  • Phenylurea Compounds / therapeutic use*
  • fms-Like Tyrosine Kinase 3 / genetics

Substances

  • Benzothiazoles
  • Phenylurea Compounds
  • quizartinib
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3