Safety and immunogenicity of a live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®) in children

Expert Rev Vaccines. 2016;15(2):153-66. doi: 10.1586/14760584.2016.1123097. Epub 2015 Dec 9.


JE-CV (IMOJEV®, Sanofi Pasteur, France) is a live attenuated virus vaccine constructed by inserting coding sequences of the prM and E structural proteins of the Japanese encephalitis SA14-14-2 virus into the genome of yellow fever 17D virus. Primary immunization with JE-CV requires a single dose of the vaccine. This article reviews clinical trials of JE-CV in children aged up to 6 years conducted in countries across South-East Asia. Strong and persistent antibody responses were observed after single primary and booster doses, with 97% of children seroprotected up to five years after booster vaccination. Models of long-term antibody persistence predict a median duration of protection of approximately 30 years after a booster dose. The safety and reactogenicity profiles of JE-CV primary and booster doses are comparable to other widely used childhood vaccines.

Keywords: IMOJEV®; Japanese encephalitis; flaviviridae; pediatrics; vaccines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies, Viral / blood
  • Asia, Southeastern
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Encephalitis, Japanese / prevention & control*
  • Humans
  • Immunization Schedule
  • Infant
  • Japanese Encephalitis Vaccines / administration & dosage
  • Japanese Encephalitis Vaccines / adverse effects*
  • Japanese Encephalitis Vaccines / immunology*
  • Membrane Glycoproteins / genetics
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / adverse effects
  • Vaccines, Attenuated / immunology
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / adverse effects
  • Vaccines, Synthetic / immunology
  • Viral Envelope Proteins / genetics
  • Yellow Fever Vaccine / genetics


  • Antibodies, Viral
  • Japanese Encephalitis Vaccines
  • Membrane Glycoproteins
  • Vaccines, Attenuated
  • Vaccines, Synthetic
  • Viral Envelope Proteins
  • Yellow Fever Vaccine
  • glycoprotein E, Japanese encephalitis virus
  • prM protein, Flavivirus