Notch Signaling: Piercing a Harness of Simplicity

Christina Helbig; Derk Amsen

doi:10.1016/j.immuni.2015.10.022

Notch Signaling: Piercing a Harness of Simplicity

Immunity. 2015 Nov 17;43(5):831-3. doi: 10.1016/j.immuni.2015.10.022.

Authors

Christina Helbig¹, Derk Amsen²

Affiliations

¹ Department of Hematopoiesis, Sanquin and Landsteiner Laboratory for Blood Research, 1066CX Amsterdam, the Netherlands.
² Department of Hematopoiesis, Sanquin and Landsteiner Laboratory for Blood Research, 1066CX Amsterdam, the Netherlands. Electronic address: d.amsen@sanquin.nl.

PMID: 26588772
DOI: 10.1016/j.immuni.2015.10.022

Abstract

The Notch pathway is an attractive therapeutic target for treatment of cancer and T cell-mediated pathology, but Notch inhibition leads to many side effects. Pinnell et al. (2015) demonstrate that oncogenic functions can be separated biochemically from other functions of Notch, opening new options for more selective targeting of this pathway.

Publication types

Comment

MeSH terms

Animals
Humans
Leukemia / metabolism*
Protein Inhibitors of Activated STAT / metabolism*
Receptor, Notch1 / metabolism*
T-Lymphocytes / metabolism*
Transcription Factors / metabolism*

Substances

Protein Inhibitors of Activated STAT
Receptor, Notch1
Transcription Factors