Not-So-Negative Selection

Immunity. 2015 Nov 17;43(5):833-5. doi: 10.1016/j.immuni.2015.11.002.


It once seemed clear that negative selection of self-specific T cells in the thymus was the major mechanism of central tolerance. But recent studies, including Legoux et al. (2015) in this issue of Immunity, show that this is not always the case.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoantigens / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Immune Tolerance / immunology*
  • T-Lymphocytes, Regulatory / immunology*


  • Autoantigens