Worming Their Way into the Picture: Microbiota Help Helminths Modulate Host Immunity

Lisa A Reynolds; B Brett Finlay

doi:10.1016/j.immuni.2015.10.025

Worming Their Way into the Picture: Microbiota Help Helminths Modulate Host Immunity

Immunity. 2015 Nov 17;43(5):840-2. doi: 10.1016/j.immuni.2015.10.025.

Authors

Lisa A Reynolds¹, B Brett Finlay²

Affiliations

¹ Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
² Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address: bfinlay@msl.ubc.ca.

PMID: 26588776
DOI: 10.1016/j.immuni.2015.10.025

Abstract

Parasitic helminths are potent regulators of host immunity, including inhibition of allergic inflammation. In this issue of Immunity, Zaiss et al. (2015) reveal that microbiota compositional shifts during helminth infection contribute to the multifaceted ways that helminths modulate host immunity.

Publication types

Comment

MeSH terms

Animals
Female
Gastrointestinal Microbiome / immunology*
Helminths / immunology*
Humans
Hypersensitivity / immunology*
Inflammation / immunology*
Inflammation / parasitology*
Intestinal Mucosa / immunology*
Intestinal Mucosa / microbiology*
Male