Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications

J Biomater Appl. 2016 Feb;30(7):1049-59. doi: 10.1177/0885328215616273. Epub 2015 Nov 20.


Prompt emergency treatment for ocular injury, particularly in a battlefield setting, is essential to preserve vision, reduce pain, and prevent secondary infection. A bandage contact lens that could be applied in the field, at the time of injury, would protect the injured ocular surface until hospital treatment is available. Cellulose, a natural polymer, is widely used in biomedical applications including bandage materials. Hydrogels synthesized from different cellulose sources, such as plants, cotton, and bacteria, can have the optical transparency and mechanical strength of contact lenses, by tailoring synthesis parameters. Thus, we optimized the fabrication of cellulose-based hydrogels and evaluated their in vivo biocompatibility and related physical properties. Our data demonstrate that along with tailorable physical properties, our novel cellulose-based hydrogels could be made with contact lens geometry, exhibit no significant signs of material toxicity after 22 days of in vivo testing, and show significant promise for use as a corneal bandage immediately following ocular trauma.

Keywords: Cellulose; bandage contact lens; biocompatibility; hydrogel; ocular injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Cellulose / chemistry*
  • Contact Lenses
  • Contact Lenses, Hydrophilic
  • Cornea / pathology
  • Corneal Injuries / prevention & control*
  • Eye Injuries / therapy*
  • Female
  • Hydrogels / chemistry*
  • Male
  • Materials Testing
  • Oxygen / chemistry
  • Permeability
  • Polymers / chemistry
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Silicones / chemistry


  • Biocompatible Materials
  • Hydrogels
  • Polymers
  • Silicones
  • Cellulose
  • Oxygen