Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors

Haematologica. 2016 Mar;101(3):e99-102. doi: 10.3324/haematol.2015.133470. Epub 2015 Nov 20.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology
  • B-Lymphocytes / pathology*
  • Chemokine CXCL10 / pharmacology
  • Chemokine CXCL11 / pharmacology
  • Chemokine CXCL9 / pharmacology
  • Chemotaxis / drug effects
  • Disease Progression
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Immunophenotyping
  • Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / mortality
  • Lymphocyte Activation / drug effects
  • Niacinamide / analogs & derivatives
  • Niacinamide / pharmacology
  • Piperazines / pharmacology
  • Predictive Value of Tests
  • Primary Cell Culture
  • Prognosis
  • ROC Curve
  • Receptor Cross-Talk / immunology*
  • Receptors, CXCR3 / genetics*
  • Receptors, CXCR3 / immunology
  • Receptors, CXCR4 / genetics*
  • Receptors, CXCR4 / immunology
  • Signal Transduction
  • Survival Analysis
  • Treatment Outcome

Substances

  • 5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)-N-ethylnicotinamide
  • Antineoplastic Agents
  • CXCL10 protein, human
  • CXCL11 protein, human
  • CXCL9 protein, human
  • CXCR3 protein, human
  • CXCR4 protein, human
  • Chemokine CXCL10
  • Chemokine CXCL11
  • Chemokine CXCL9
  • Piperazines
  • Receptors, CXCR3
  • Receptors, CXCR4
  • Niacinamide