Establishment and Dysfunction of the Blood-Brain Barrier

Cell. 2015 Nov 19;163(5):1064-1078. doi: 10.1016/j.cell.2015.10.067.


Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Astrocytes / metabolism
  • Blood-Brain Barrier / cytology
  • Blood-Brain Barrier / physiology
  • Blood-Brain Barrier / physiopathology*
  • Endothelial Cells / metabolism
  • Humans
  • Membrane Transport Proteins / metabolism
  • Nervous System Diseases / genetics
  • Nervous System Diseases / pathology
  • Nervous System Diseases / physiopathology*
  • Pericytes / cytology


  • Membrane Transport Proteins