Update on Molecular Biology of Lung Development--Transcriptomics

Clin Perinatol. 2015 Dec;42(4):685-95. doi: 10.1016/j.clp.2015.08.001.


This article highlights some of the significant advances in our understanding of lung developmental biology made over the last few years, which challenge existing paradigms and are relevant to a fundamental understanding of this process. Additional comments address how these new insights may be informative for chronic lung diseases that occur, or initiate, in the neonatal period. This is not meant to be an exhaustive review of the molecular biology of lung development. For a more comprehensive, contemporary review of the cellular and molecular aspects of lung development, readers can refer to recent reviews by others.

Keywords: Airway; Alveoli; Epithelium; Mesenchyme; Progenitor cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental*
  • Humans
  • Lung / embryology*
  • Lung / growth & development
  • Lung / metabolism
  • Mesoderm / embryology
  • Mesoderm / growth & development
  • Mesoderm / metabolism
  • MicroRNAs
  • Pulmonary Alveoli / embryology
  • Pulmonary Alveoli / growth & development
  • Pulmonary Alveoli / metabolism
  • RNA, Messenger / metabolism
  • Respiratory Mucosa / embryology
  • Respiratory Mucosa / growth & development
  • Respiratory Mucosa / metabolism
  • Stem Cells / metabolism
  • Transcriptome*


  • MicroRNAs
  • RNA, Messenger