Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity

Clin Perinatol. 2015 Dec;42(4):697-718. doi: 10.1016/j.clp.2015.08.002. Epub 2015 Oct 1.


Premature infants suffer significant respiratory morbidity during infancy with long-term negative consequences on health, quality of life, and health care costs. Enhanced susceptibility to a variety of infections and inflammation play a large role in early and prolonged lung disease following premature birth, although the mechanisms of susceptibility and immune dysregulation are active areas of research. This article reviews aspects of host-pathogen interactions and immune responses that are altered by preterm birth and that impact chronic respiratory morbidity in these children.

Keywords: Bronchopulmonary dysplasia; Chronic lung disease of prematurity; Lymphocytes; Neonatal immunology; Neonatal infection; Prematurity; Preterm; Virus.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bronchopulmonary Dysplasia / immunology*
  • Chorioamnionitis / immunology
  • Cytomegalovirus Infections / immunology*
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Inflammation
  • Lung / immunology*
  • Pneumonia / immunology*
  • Pregnancy
  • Quality of Life
  • Respiratory Syncytial Virus Infections / immunology*
  • Staphylococcal Infections / immunology*