Biomarkers, Early Diagnosis, and Clinical Predictors of Bronchopulmonary Dysplasia

Clin Perinatol. 2015 Dec;42(4):739-54. doi: 10.1016/j.clp.2015.08.004. Epub 2015 Oct 1.


The pathogenesis of bronchopulmonary dysplasia (BPD) is multifactorial, and the clinical phenotype of BPD is extremely variable. Several clinical and laboratory biomarkers have been proposed for the early identification of infants at higher risk of BPD and for determination of prognosis of infants with a diagnosis of BPD. The authors review available literature on prediction tools and biomarkers of BPD, using clinical variables and biomarkers based on imaging, lung function measures, and measurements of various analytes in different body fluids that have been determined to be associated with BPD either in a targeted manner or by unbiased omic profiling.

Keywords: Biomarkers; Bronchopulmonary dysplasia; Early diagnosis; Infant; Premature; Prognosis; Pulmonary hypertension; Systems biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism
  • Body Fluids / chemistry
  • Breath Tests
  • Bronchoalveolar Lavage Fluid / chemistry
  • Bronchopulmonary Dysplasia / diagnosis*
  • Bronchopulmonary Dysplasia / genetics
  • Bronchopulmonary Dysplasia / metabolism
  • Cytokines / metabolism*
  • Decision Support Techniques
  • Early Diagnosis
  • Echocardiography
  • Humans
  • Hypertension, Pulmonary / diagnostic imaging
  • Infant, Newborn
  • Infant, Premature
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Lung / diagnostic imaging
  • Lung / metabolism*
  • Magnetic Resonance Imaging
  • Prognosis
  • Radiography, Thoracic
  • Reactive Oxygen Species / metabolism
  • Respiratory Function Tests
  • Tomography, X-Ray Computed
  • Transcriptome


  • Biomarkers
  • Cytokines
  • Intercellular Signaling Peptides and Proteins
  • Reactive Oxygen Species