Genetics of Sarcoidosis

Clin Chest Med. 2015 Dec;36(4):569-84. doi: 10.1016/j.ccm.2015.08.002. Epub 2015 Oct 1.


Sarcoidosis is a disease with highly variable presentation and progression; although it is hypothesized that disease phenotype is related to genetic variation, how much of this variability is driven by genetic factors is not known. The HLA region is the most strongly and consistently associated genetic risk factor for sarcoidosis, supporting the notion that sarcoidosis is an exposure-mediated immunologic disease. Most of the genetic etiology of sarcoidosis remains unknown in terms of the specific variants that increase risk in various populations, their biologic functions, and how they interact with environmental exposures.

Keywords: Genetic epidemiology; HLA region; Immune-mediated disease; Sarcoidosis.

Publication types

  • Review

MeSH terms

  • Genetic Predisposition to Disease
  • HLA Antigens / genetics*
  • Humans
  • Risk Factors
  • Sarcoidosis / genetics*


  • HLA Antigens