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Review
. 2015 Dec;35(4):745-64.
doi: 10.1016/j.cll.2015.07.004. Epub 2015 Aug 8.

Borrelia Burgdorferi Pathogenesis and the Immune Response

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Review

Borrelia Burgdorferi Pathogenesis and the Immune Response

Mary Petzke et al. Clin Lab Med. .

Abstract

Borrelia burgdorferi is the tick-borne etiologic agent of Lyme disease. The spirochete must negotiate numerous barriers in order to establish a disseminated infection in a mammalian host. These barriers include migration from the feeding tick midgut to the salivary glands, deposition in skin, manipulation or evasion of the localized host immune response, adhesion to and extravasation through an endothelial barrier, hematogenous dissemination, and establishment of infection in distal tissue sites. Borrelia burgdorferi proteins that mediate many of these processes and the nature of the host response to infection are described.

Keywords: Adhesins; Genotypic variation; Immune evasion; Lyme disease; Type I interferon.

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