Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats

J Complement Integr Med. 2016 Mar;13(1):9-16. doi: 10.1515/jcim-2015-0020.


Background: The study investigated the antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats.

Methods: The phytochemical constituents, total polyphenol content and ferric reducing antioxidant power (FRAP) were estimated in the G. cambogia extract (GE). Male Wistar rats were fed with either standard rodent diet or 30% high-fat diet and administered with GE at a dose of 400 mg/kg body weight/day for 10 weeks. At the end, lipid profile and oxidative stress parameters were estimated.

Results: The analyses revealed the presence of carbohydrates, proteins, sterols, tannins, flavonoids and saponins in GE. The total polyphenol content and FRAP of GE were 82.82±7.64 mg of gallic acid equivalents and 260.49±10.18 µM FRAP per gram of the GE. High-fat feeding elevated plasma total cholesterol (TC), triacylglycerol (TAG), non-high-density lipoprotein-cholesterol (non-HDL-C), malondialdehyde (MDA), reduced HDL-C and blood antioxidants, glutathione (GSH), glutathione peroxidase (GPx), catalase. Increase in total oxidant status (TOS), oxidative stress index (OSI) and decrease in the total antioxidant status (TAS) were observed in plasma, liver and kidney of fat-fed rats. Administration of GE decreased food intake, plasma TC, TAG, non HDL-C, MDA, increased HDL-C and blood antioxidants GSH, GPx, catalase. GE also reduced TOS, OSI and elevated TAS in plasma and liver of fat-fed rats. Renal OSI was significantly reduced upon GE treatment.

Conclusions: Our study demonstrated that GE is effective in ameliorating high-fat-diet-induced hyperlipidemia and oxidative stress.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Biomarkers / metabolism
  • Cholesterol / metabolism
  • Diet, High-Fat
  • Eating / physiology
  • Ethanol / pharmacology*
  • Garcinia cambogia*
  • Hyperlipidemias / drug therapy*
  • Hypolipidemic Agents / pharmacology*
  • Male
  • Malondialdehyde / metabolism
  • Oxidative Stress / physiology
  • Phytotherapy / methods
  • Plant Extracts / pharmacokinetics*
  • Rats, Wistar
  • Triglycerides / metabolism


  • Antioxidants
  • Biomarkers
  • Hypolipidemic Agents
  • Plant Extracts
  • Triglycerides
  • Ethanol
  • Malondialdehyde
  • Cholesterol