Metabolic impact of 100% fruit juice consumption on antioxidant/oxidant status and lipid profiles of adults: An Evidence-Based review

Crit Rev Food Sci Nutr. 2017 Jan 2;57(1):152-162. doi: 10.1080/10408398.2015.1102861.


One hundred percent fruit juice (FJ) contains bioactive compounds with antioxidant activity. As such, this fruit form has the potential to improve antioxidant status and mediate outcomes influenced by redox status. A systematic review of the literature published between 1995 and 2013 was conducted using PubMed database to evaluate associations between intake of 100% FJ and markers of antioxidant/oxidant status and blood lipid levels in healthy, free-living adults ≥18 years. Data extraction and analysis was conducted according to the Academy of Nutrition and Dietetics Evidence Analysis Process. Limited evidence from ten clinical trials meeting inclusion/exclusion criteria suggests potential improvements in a variety of antioxidant or oxidants biomarkers postconsumption of 100% FJ. Weak evidence from five studies suggests that one or more blood lipid measures may be positively influenced by consumption of 100% FJ. Heterogeneity in study methodology including biomarkers, 100% FJ type, dosage, and intervention duration precludes the ability to make evidence-based recommendations regarding a specific dose-duration-juice effect. Key characteristics in study designs were identified which must either be controlled or statistically adjusted for in future investigations in order to obtain a more accurate understanding of the complex relationship between metabolic outcomes and consumption of 100% FJ in context of a healthy dietary pattern.

Keywords: 100% fruit juice; Evidence Analysis Library; adults; antioxidant status; cholesterol; functional foods; lipids; oxidative stress.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Antioxidants / adverse effects
  • Antioxidants / analysis
  • Antioxidants / therapeutic use*
  • Biomarkers / blood
  • Clinical Trials as Topic
  • Diet, Healthy
  • Evidence-Based Medicine*
  • Fruit / adverse effects
  • Fruit / chemistry*
  • Fruit and Vegetable Juices / adverse effects
  • Fruit and Vegetable Juices / analysis*
  • Functional Food / adverse effects
  • Functional Food / analysis*
  • Humans
  • Hyperlipidemias / blood
  • Hyperlipidemias / etiology
  • Hyperlipidemias / prevention & control*
  • Oxidative Stress*
  • Reproducibility of Results


  • Antioxidants
  • Biomarkers