RNA editing by ADAR1 marks dsRNA as "self"

Cell Res. 2015 Dec;25(12):1283-4. doi: 10.1038/cr.2015.135. Epub 2015 Nov 24.

Abstract

A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.

Publication types

  • Comment

MeSH terms

  • Adenosine Deaminase / metabolism*
  • Animals
  • DEAD-box RNA Helicases / metabolism*
  • Embryo Loss / genetics*
  • RNA Editing*
  • RNA, Double-Stranded / metabolism*

Substances

  • RNA, Double-Stranded
  • Adenosine Deaminase
  • DEAD-box RNA Helicases