The multifaceted roles of the HORMA domain in cellular signaling

J Cell Biol. 2015 Nov 23;211(4):745-55. doi: 10.1083/jcb.201509076.


The HORMA domain is a multifunctional protein-protein interaction module found in diverse eukaryotic signaling pathways including the spindle assembly checkpoint, numerous DNA recombination/repair pathways, and the initiation of autophagy. In all of these pathways, HORMA domain proteins occupy key signaling junctures and function through the controlled assembly and disassembly of signaling complexes using a stereotypical "safety belt" peptide interaction mechanism. A recent explosion of structural and functional work has shed new light on these proteins, illustrating how strikingly similar structural mechanisms give rise to radically different functional outcomes in each family of HORMA domain proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Autophagy
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / physiology
  • DNA-Directed DNA Polymerase / chemistry
  • DNA-Directed DNA Polymerase / physiology
  • Humans
  • M Phase Cell Cycle Checkpoints
  • Mad2 Proteins / chemistry
  • Mad2 Proteins / physiology*
  • Protein Interaction Domains and Motifs
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / physiology
  • Signal Transduction*
  • Structural Homology, Protein


  • DNA-Binding Proteins
  • HOP1 protein, S cerevisiae
  • Mad2 Proteins
  • REV7 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • DNA-Directed DNA Polymerase

Associated data

  • PDB/1DUJ
  • PDB/2QYF
  • PDB/2V64
  • PDB/4AEZ
  • PDB/4YK8