J Nutr Sci Vitaminol (Tokyo). 2015:61 Suppl:S92-4. doi: 10.3177/jnsv.61.S92.


Well-regulated eating habits are said to be important for health. A major breakthrough was the discovery of the negative regulatory feedback for transcription via the binding of Clock/Bmal1 to E-box, which forms the basis of biological clocks. Well-regulated eating habits normalize the liver clock gene, the rhythm of CYP7A1 gene, and blood cholesterol levels through insulin secretion. Moreover, well-regulated eating habits actively contribute to better lipid metabolism such as obesity, even if animals ingest a high-fat diet. From reported results so far, chrononutition has two important functions: 1) meal timing is important for our health, and 2) meal timing entrains our body clock.

Publication types

  • Review

MeSH terms

  • Animals
  • CLOCK Proteins / genetics
  • CLOCK Proteins / metabolism
  • Cholesterol / blood
  • Cholesterol 7-alpha-Hydroxylase / genetics
  • Cholesterol 7-alpha-Hydroxylase / metabolism
  • Chronobiology Phenomena*
  • Circadian Clocks / physiology
  • Diet*
  • Diet, High-Fat / adverse effects
  • Disease Models, Animal
  • Feeding Behavior*
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Lipid Metabolism
  • Liver / metabolism
  • Meals
  • Obesity / etiology
  • Obesity / metabolism
  • Time Factors


  • Insulin
  • Cholesterol
  • Cholesterol 7-alpha-Hydroxylase
  • CLOCK Proteins