The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

Douglas Vernimmen; Wendy A Bickmore

doi:10.1016/j.tig.2015.10.004

The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

Trends Genet. 2015 Dec;31(12):696-708. doi: 10.1016/j.tig.2015.10.004.

Authors

Douglas Vernimmen¹, Wendy A Bickmore²

Affiliations

¹ The Roslin Institute, Developmental Biology Division, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. Electronic address: douglas.vernimmen@roslin.ed.ac.uk.
² MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.

PMID: 26599498
DOI: 10.1016/j.tig.2015.10.004

Abstract

Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Transcriptional Activation*