The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

Trends Genet. 2015 Dec;31(12):696-708. doi: 10.1016/j.tig.2015.10.004.


Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Enhancer Elements, Genetic*
  • Promoter Regions, Genetic*
  • Transcriptional Activation*