Effects of Prednisolone, L-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas

J Pediatr Hematol Oncol. 2016 Jan;38(1):e42-9. doi: 10.1097/MPH.0000000000000484.

Abstract

The aim of this study is to determine the effects of L-asparaginase (L-ASP), corticosteroids (CSs), and antilipidemics, separately and in combination, on the lipid profiles and the liver and pancreas histology in mice. This study included 8 groups of 7 mice each. Before any drug administration, serum samples were taken from all of the mice. Then, normal saline was applied to the control group, and a medication or combination of medications was applied to the other groups. Levels of triglycerides, cholesterol (COL), and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined, and the livers and pancreases were evaluated histologically at the end of the study. Triglycerides increased significantly in the CS-only and the L-ASP-only groups, COL increased significantly in the CS-only group, and HDL increased significantly in the CS-only and the antilipidemic-only groups. LDL was significantly lower in the CS-only and the L-ASP-only groups. CSs and L-ASP were significantly effective in liver necrosis, L-ASP was significantly effective in liver balloon degeneration, and CS were significantly effective in pancreas vacuolization. Triglyceride measurement is recommended before/during CS and/or L-ASP treatment. Starting with an antilipidemic agent can be considered to avoid possible complications in patients with significantly high rates. Indicators of a possible liver or pancreas injury should also be considered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / adverse effects
  • Animals
  • Antineoplastic Agents / adverse effects*
  • Asparaginase / adverse effects
  • Drug Combinations
  • Female
  • Gemfibrozil / pharmacology
  • Hypolipidemic Agents / pharmacology*
  • Lipids / blood*
  • Liver / drug effects*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Models, Animal
  • Pancrelipase / drug effects*
  • Prednisolone / adverse effects

Substances

  • Adrenal Cortex Hormones
  • Antineoplastic Agents
  • Drug Combinations
  • Hypolipidemic Agents
  • Lipids
  • Pancrelipase
  • Prednisolone
  • Asparaginase
  • Gemfibrozil