RNA-catalysed synthesis of complementary-strand RNA

J A Doudna; J W Szostak

doi:10.1038/339519a0

RNA-catalysed synthesis of complementary-strand RNA

Nature. 1989 Jun 15;339(6225):519-22. doi: 10.1038/339519a0.

Authors

J A Doudna¹, J W Szostak

Affiliation

¹ Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.

PMID: 2660003
DOI: 10.1038/339519a0

Abstract

The Tetrahymena ribozyme can splice together multiple oligonucleotides aligned on a template strand to yield a fully complementary product strand. This reaction demonstrates the feasibility of RNA-catalysed RNA replications.

MeSH terms

Animals
Base Sequence
Introns
Molecular Sequence Data
Oligonucleotides / metabolism
RNA Splicing
RNA, Catalytic
RNA, Ribosomal / genetics
RNA, Ribosomal / metabolism*
Spermidine / pharmacology
Templates, Genetic
Tetrahymena / genetics*

Substances

Oligonucleotides
RNA, Catalytic
RNA, Ribosomal
Spermidine