Dietary phytochemical index and the risk of insulin resistance and β-cell dysfunction: a prospective approach in Tehran lipid and glucose study

Int J Food Sci Nutr. 2015;66(8):950-5. doi: 10.3109/09637486.2015.1111867.


Background: In this study, we aimed to investigate the association of dietary phytochemical index (DPI) with insulin resistance, β-cell dysfunction, and insulin sensitivity.

Methods: This longitudinal study was conducted on 1141 participants of the Tehran Lipid and Glucose Study. Dietary data were collected using a validated semi-quantitative FFQ with 168 food items at baseline and DPI was calculated. Fasting serum insulin and glucose were measured at baseline and again after a 3-year of follow-up.

Results: After 3-years of follow-up, the risk of hyperinsulinemia significantly decreased by 65 (OR = 0.35, 95% CI = 0.21-0.60) and 86% (OR = 0.14, 0.07-0.29), in the third and fourth quartile categories of DPI, respectively. The occurrence of insulin resistance and insulin insensitivity in participants with higher DPI was significantly lower than the others (OR = 0.48, 95% CI = 0.25-0.93 and OR = 0.11, 95% CI = 0.05-0.24, respectively).

Conclusion: Higher consumption of phytochemical-rich foods may have protective effects against development of insulin resistance.

Keywords: Dietary phytochemical index; fasting serum insulin; insulin resistance; β-cell dysfunction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Body Mass Index
  • Diet*
  • Energy Intake
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperinsulinism / blood
  • Hyperinsulinism / diet therapy
  • Insulin / blood
  • Insulin Resistance*
  • Insulin-Secreting Cells / drug effects*
  • Insulin-Secreting Cells / pathology
  • Iran
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Nutrition Assessment
  • Phytochemicals / administration & dosage*
  • Prospective Studies
  • Risk Factors
  • Surveys and Questionnaires


  • Blood Glucose
  • Insulin
  • Phytochemicals