Hypodontia, a prospective predictive marker for tumor?

Oral Dis. 2016 May;22(4):265-73. doi: 10.1111/odi.12400. Epub 2016 Jan 13.


Tooth agenesis and tumor are two totally different diseases occurring at different ages. In the past 10 years, more and more evidences suggested there was a relationship between them. High prevalence of breast, colon, lung, and ovary tumor was observed in tooth agenesis patients. But it is still controversial. Therefore, to have a greater understanding of the possible association, a critical review on molecular association for genes involving tooth agenesis and tumorigenesis is necessary. In this current review, we summarized the reported cases of tooth agenesis with different kinds of tumors and the molecular relationship between these two diseases through causative genes. The results indicated tooth agenesis might be a prospective predictive marker for tumor. Through this review, we want to draw more attention on this topic and hope it will be an effective way to predict the risk of tumor.

Keywords: AXIN2 gene; predictive marker; tooth agenesis; tumor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anodontia / genetics*
  • Axin Protein / genetics
  • Breast Neoplasms / genetics*
  • Colorectal Neoplasms / genetics*
  • Female
  • Humans
  • Lung Neoplasms / genetics*
  • MSX1 Transcription Factor / genetics
  • Ovarian Neoplasms / genetics*
  • PAX9 Transcription Factor / genetics
  • Wnt Proteins / genetics


  • AXIN2 protein, human
  • Axin Protein
  • MSX1 Transcription Factor
  • MSX1 protein, human
  • PAX9 Transcription Factor
  • PAX9 protein, human
  • WNT10A protein, human
  • Wnt Proteins