Hypotension was observed in 11 cases of hypoglycemic condition of 7 diabetic patients suffering from autonomic neuropathy. Following the iv. administration of glucose the hypotension became stronger. Upon glucagon the blood pressure kept decreasing. Neuropathy of the symphathetic nervous system, the osmotic effect of glucose and the vasodilating effect of glucagon were the causes of the hypotension. Hypotension in hypoglycemia is a symptom referring to autonomic neuropathy. Hypotension aggravates the neuroglycopenic disturbance. Slow injection of glucose solution moderates the decrease of the blood pressure. The use of glucagon in the hypoglycemia of diabetic patients with autonomic neuropathy must be subjected to consideration.