Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence

Oncogene. 1989 Jun;4(6):805-6.


Our recent studies suggested that the ret proto-oncogene protein is a cell surface receptor with a tyrosine kinase domain. However, the sequence of its cDNA lacked an amino-terminal signal sequence characteristic of membrane proteins. In the present study we have isolated and sequenced an additional cDNA clone. The nucleotide sequence of the cDNA obtained indicated that the 5' terminal 330 nucleotides differs from the published sequence of the ret proto-oncogene. In addition, the sequence contains an open reading frame with an amino-terminal signal sequence.

MeSH terms

  • Base Sequence
  • Blotting, Northern
  • Cell Line
  • Cloning, Molecular
  • Codon
  • DNA, Neoplasm
  • Drosophila Proteins*
  • Humans
  • Molecular Sequence Data
  • Protein Sorting Signals / genetics*
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-ret
  • Proto-Oncogenes*
  • Receptor Protein-Tyrosine Kinases*


  • Codon
  • DNA, Neoplasm
  • Drosophila Proteins
  • MAS1 protein, human
  • Protein Sorting Signals
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Ret protein, Drosophila

Associated data

  • GENBANK/X15262