Telelap ALF-X vs Standard Laparoscopy for the Treatment of Early-Stage Endometrial Cancer: A Single-Institution Retrospective Cohort Study

J Minim Invasive Gynecol. Mar-Apr 2016;23(3):378-83. doi: 10.1016/j.jmig.2015.11.006. Epub 2015 Nov 18.

Abstract

Study objective: To compare the surgical and clinical outcomes of patients affected by early-stage endometrial cancer treated using the Telelap ALF-X platform versus conventional laparoscopic surgery.

Design: Single institution retrospective cohort study (Canadian Task Force classification II-2).

Setting: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome, Italy.

Patients: The study involved 89 patients affected by early-stage endometrial cancer who underwent elective surgical staging between October 2013 and September 2014. Among them, 43 (48.3%) underwent Telelap ALF-X staging (ALF-X group), and 46 (51.7%) underwent conventional laparoscopic staging (laparoscopic group).

Interventions: All selected patients underwent laparoscopic staging with radical hysterectomy (class A sec Querleu-Morrow), bilateral salpingo-oophorectomy, and pelvic lymphadenectomy if required. The 2 surgical groups were further divided into patients who did not require pelvic lymphadenectomy (subgroup 1) and those who underwent pelvic lymphadenectomy (subgroup 2).

Measurements and main results: In the ALF-X group, the median operative time was 128 minutes (range, 69-260 minutes) for subgroup 1 and 193 minutes (range, 129-290 minutes) for subgroup 2. In the laparoscopic group, the median operative time was 82 minutes (range, 25-180 minutes) in subgroup 1 and 104 minutes (range, 36-160 minutes) in subgroup 2. The difference in operative time between subgroups was statistically significant in both the ALF-X and laparoscopic groups (p = .000). In subgroup 1 of the ALF-X group, there was 1 conversion to standard laparoscopy (2.3%) and 2 conversions to laparotomy (4.7%) (p = .234). No conversions to laparotomy occurred in the laparoscopic group. Postoperative complications included 1 case of pelvic hematoma (2.3%) in subgroup 1 of the ALF-X group and 1 case of subocclusion and 1 case of pulmonary edema (4.3%) in subgroup 1 of the laparoscopic group.

Conclusion: Based on operative outcomes and complication rates, our results suggest that the Telelap ALF-X approach is feasible and safe for endometrial cancer staging; however, further studies are needed to definitively assess the role of Telelap ALF-X early-stage endometrial cancer staging.

Keywords: ALF-X; Endometrial cancer; Endoscopy; Laparoscopy; Robotic surgery.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Animals
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / surgery*
  • Feasibility Studies
  • Female
  • Humans
  • Hysterectomy / instrumentation*
  • Hysterectomy / methods
  • Italy
  • Laparoscopy* / methods
  • Laparotomy / methods
  • Laparotomy / statistics & numerical data*
  • Lymph Node Excision / instrumentation*
  • Lymph Node Excision / methods
  • Lymph Node Excision / statistics & numerical data
  • Middle Aged
  • Operative Time
  • Postoperative Complications / etiology
  • Postoperative Complications / surgery*
  • Retrospective Studies
  • Robotic Surgical Procedures* / methods
  • Treatment Outcome