Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa

Sci Rep. 2015 Nov 25;5:17281. doi: 10.1038/srep17281.

Abstract

Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based on capsular epitopes will relate to local epidemiology of S. agalactiae serotypes and successful management of critical infections depends on timely therapy with effective antibiotics. This is the first report on serotype distribution and antimicrobial susceptibility of S. agalactiae in pregnant women from a Central African region. Serotypes V, III, and Ib accounted for 88/109 (81%) serotypes and all isolates were susceptible to penicillin and clindamycin while 13% showed intermediate susceptibility to erythromycin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Clindamycin / pharmacology
  • DNA, Bacterial / genetics
  • DNA, Bacterial / metabolism
  • Drug Resistance, Bacterial
  • Female
  • Gabon / epidemiology
  • Humans
  • Microbial Sensitivity Tests
  • Multiplex Polymerase Chain Reaction
  • Penicillins / pharmacology
  • Pregnancy
  • Serogroup
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology*
  • Streptococcal Infections / pathology
  • Streptococcus agalactiae / drug effects*
  • Streptococcus agalactiae / genetics
  • Streptococcus agalactiae / isolation & purification
  • Vagina / microbiology

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Penicillins
  • Clindamycin