Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr;216(3):135-45.
doi: 10.1016/j.rce.2015.09.003. Epub 2015 Oct 23.

Obstetric Antiphospholipid Syndrome

[Article in English, Spanish]
Affiliations

Obstetric Antiphospholipid Syndrome

[Article in English, Spanish]
E Esteve-Valverde et al. Rev Clin Esp. .

Abstract

Obstetric antiphospholipid syndrome is an acquired autoimmune disorder that is associated with various obstetric complications and, in the absence of prior history of thrombosis, with the presence of antiphospholipid antibodies directed against other phospholipids, proteins called cofactors or PL-cofactor complexes. Although the obstetric complications have been related to the procoagulant properties of antiphospholipid antibodies, pathological studies of human placenta have shown the proinflammatory capacity of antiphospholipid antibodies via the complement system and proinflammatory cytokines. There is no general agreement on which antiphospholipid antibodies profile (laboratory) confers the greatest obstetric risk, but the best candidates are categories I and IIa. Combined treatment with low doses of aspirin and heparin achieves good obstetric and maternal outcomes. In this study, we also review the therapeutic possibilities in refractory cases, although the likelihood of progressing to other autoimmune diseases is low. We briefly comment on incomplete obstetric antiphospholipid syndrome, also known as antiphospholipid antibody-mediated pregnancy morbidity syndrome.

Keywords: Abortos recurrentes; Anticuerpos antifosfolipídicos; Antiphospholipid antibodies; Embarazo; Fetal loss; Obstetric antiphospholipid syndrome; Preeclampsia; Pregnancy; Pérdidas fetales; Recurrent miscarriages; Síndrome antifosfolipídico obstétrico.

Similar articles

See all similar articles

Cited by 1 article

LinkOut - more resources

Feedback