Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries

Lancet. 2016 Jan 9;387(10014):188-98. doi: 10.1016/S0140-6736(15)00547-4. Epub 2015 Nov 18.


Access to quality-assured antimicrobials is regarded as part of the human right to health, yet universal access is often undermined in low-income and middle-income countries. Lack of access to the instruments necessary to make the correct diagnosis and prescribe antimicrobials appropriately, in addition to weak health systems, heightens the challenge faced by prescribers. Evidence-based interventions in community and health-care settings can increase access to appropriately prescribed antimicrobials. The key global enablers of sustainable financing, governance, and leadership will be necessary to achieve access while preventing excess antimicrobial use.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / diagnosis
  • Bacterial Infections / drug therapy
  • Delivery of Health Care
  • Developing Countries*
  • Diagnostic Tests, Routine
  • Drug Resistance, Microbial
  • Drugs, Generic
  • Evidence-Based Practice
  • Financing, Organized
  • Health Services Accessibility*
  • Humans
  • Inappropriate Prescribing
  • Point-of-Care Systems
  • Practice Guidelines as Topic
  • Primary Prevention
  • Quality Control
  • Vaccination


  • Anti-Bacterial Agents
  • Drugs, Generic