Pregnancy and Thoracic Aortic Disease: Managing the Risks

Can J Cardiol. 2016 Jan;32(1):78-85. doi: 10.1016/j.cjca.2015.09.003. Epub 2015 Sep 18.


The most common aortopathies in women of childbearing age are bicuspid aortic valve, coarctation of the aorta, Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome, SMAD3 aortopathy, Turner syndrome, and familial thoracic aneurysm and dissection. The hemodynamic and hormonal changes of pregnancy increase the risk of progressive dilatation or dissection of the aorta in these women. The presence of hypertension increases the risk further. Therefore, appropriate preconception counselling is advised. For women who become pregnant, serial follow-up by a specialized multidisciplinary team throughout pregnancy and postpartum period is required. In this review we discuss risk assessment and management strategies for women with aortopathies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aorta, Thoracic*
  • Aortic Diseases / diagnosis*
  • Aortic Diseases / therapy*
  • Disease Management*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications, Cardiovascular*