Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Nov 9;10:1-9.
doi: 10.4137/IMI.S25054. eCollection 2015.

Current Perspectives on the Beneficial Role of Ginkgo Biloba in Neurological and Cerebrovascular Disorders

Affiliations
Free PMC article
Review

Current Perspectives on the Beneficial Role of Ginkgo Biloba in Neurological and Cerebrovascular Disorders

Kevin M Nash et al. Integr Med Insights. .
Free PMC article

Abstract

Ginkgo biloba extract is an alternative medicine available as a standardized formulation, EGb 761(®), which consists of ginkgolides, bilobalide, and flavonoids. The individual constituents have varying therapeutic mechanisms that contribute to the pharmacological activity of the extract as a whole. Recent studies show anxiolytic properties of ginkgolide A, migraine with aura treatment by ginkgolide B, a reduction in ischemia-induced glutamate excitotoxicity by bilobalide, and an alternative antihypertensive property of quercetin, among others. These findings have been observed in EGb 761 as well and have led to clinical investigation into its use as a therapeutic for conditions such as cognition, dementia, cardiovascular, and cerebrovascular diseases. This review explores the therapeutic mechanisms of the individual EGb 761 constituents to explain the pharmacology as a whole and its clinical application to cardiovascular and neurological disorders, in particular ischemic stroke.

Keywords: Alzheimer’s disease; Ginkgo biloba; antioxidants; flavonoids; ischemic stroke.

Figures

Figure 1
Figure 1
Structures of EGb 761 constituents.

Similar articles

See all similar articles

Cited by 23 articles

See all "Cited by" articles

References

    1. Barnes PM, Bloom B, Nahin R. CDC National Health Statistics Report #12. Complimentary and alternative medicine use among adults and children. United States, 2007. Natl Health Stat Report. 2008;12:1–23. - PubMed
    1. Smith JV, Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol. 2004;64:465–72. - PubMed
    1. Zimmermann M, Colciaghi F, Cattabeni F, Di Luca M. Ginkgo biloba extract: from molecular mechanisms to the treatment of Alzhelmer’s disease. Cell Mol Biol (Noisy-le-grand) 2002;48:613–23. - PubMed
    1. Jacobs BP, Browner WS. Ginkgo biloba: a living fossil. Am J Med. 2000;108:341–2. - PubMed
    1. Gavrilova SI, Preuss UW, Wong JW, et al. Group GISc Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial. Int J Geriatr Psychiatry. 2014;29:1087–95. - PubMed

LinkOut - more resources

Feedback