Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: randomized multicenter split-mouth clinical trial

Head Face Med. 2015 Nov 26;11:37. doi: 10.1186/s13005-015-0094-5.


Background: Impacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery.

Methods: Fifty-six patients (23 male, 33 female) who provide the inclusion criteria were selected to participate in this study. The evaluation of the facial swelling was performed by using a horizontal and vertical guide. The pain was evaluated in the postoperative period using a visual analog scale (VAS) of 100 mm.

Results: Horizontal and vertical measurements showed more swelling at the control side (without PRF) in 3th day postoperatively (p < 0.05). There were no statistically significant differences regarding pain among the groups.

Conclusion: As a conclusion, PRF seems to be effectiveness on postoperative horizontal swelling after third molar surgery. PRF could be used on a routine basis after third molar extraction surgery.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Blood Platelets
  • Edema / drug therapy*
  • Edema / etiology
  • Female
  • Fibrin / therapeutic use*
  • Humans
  • Male
  • Pain Measurement
  • Pain, Postoperative / drug therapy*
  • Tooth Extraction / adverse effects*
  • Tooth, Impacted / surgery*
  • Treatment Outcome
  • Young Adult


  • Fibrin