Assessment of ovarian reserve in euthyroid adolescents with Hashimoto thyroiditis

Gynecol Endocrinol. 2016;32(4):306-10. doi: 10.3109/09513590.2015.1116510. Epub 2015 Nov 26.


Aim: We aimed to investigate the ovarian function and reserve in euthyroid adolescents (TSH < 2.5 mIU/L) diagnosed with Hashimoto thyroiditis (HT).

Methods: This case-control study included 30 adolescent girls (mean age 15.1 ± 1.4 years) newly diagnosed as HT with presence of high thyroid antibodies with gland heterogeneity in ultrasound and age-matched 30 healthy female subjects. Anti-ovarian antibody (AOAb), LH/FSH ratio, estradiol, anti-mullerian hormone (AMH), inhibin-B, total testosterone, antral follicle count, ovarian volumes and uterine length were measured. The clinical, laboratory, and ultrasound data of the HT and control groups were compared.

Results: There were no significant differences between the girls with HT and healthy controls in relation to LH/FSH ratio, estradiol and inhibin-B levels. AOAb (p = 0.02), AMH (p = 0.007) and total testosterone levels were higher in HT group than the control group (p = 0.03). AOAb level was found to be positively correlated with LH/FSH ratio (p = 0.03), AMH (p = 0.01) and inhibin-B (p < 0.001) in HT group.

Conclusion: This study demonstrated that the adolescent girls diagnosed with autoimmune thyroiditis had normal ovarian reserve based on measurements of AMH, inhibin B, FSH, LH/FSH ratio, estradiol and antral follicle counts.

Keywords: Adolescent; Hashimoto thyroiditis; anti-ovarian antibody; autoimmunity; ovarian reserve.

MeSH terms

  • Adolescent
  • Anti-Mullerian Hormone / blood
  • Antibodies / blood
  • Case-Control Studies
  • Female
  • Hashimoto Disease / blood
  • Hashimoto Disease / diagnostic imaging
  • Hashimoto Disease / physiopathology*
  • Humans
  • Inhibins / blood
  • Ovarian Follicle / diagnostic imaging
  • Ovarian Reserve*
  • Ultrasonography


  • Antibodies
  • inhibin B
  • Inhibins
  • Anti-Mullerian Hormone