COX-2 gene variants in bipolar disorder-I

Psychiatr Danub. 2015 Dec;27(4):385-9.


Background: Bipolar disorder-I (BD-I) is a complex illness, and multiple genes and environmental factors determine its pathogenesis. Several studies have ascertained that BD-I and inflammation are linked through shared genetic polymorphisms and gene expression, as well as altered cytokine levels. COX-2 gene polymorphisms affecting COX-2 levels may be associated with BD-I by altering the inflammatory response.

Subjects and methods: We investigated COX-2-765G→C and COX-2-1195A→G gene polymorphisms, which might be related for BD-I. The present analyses are based on 180 subjects with bipolar I disorder-I and 170 non-bipolar subjects. Genotyping of COX-2 gene polymorphisms (COX-2-765G→C, COX-2-1195A→G) were detected by PCR-RFLP.

Results: We found a positive association of COX-2 gene variants for development of BD-I. There were statistically significant differences in COX-2-1195A→G genotypes and alleles between the controls and patients (p:0.000; p:0.000). The indivuals with COX-2-1195A→G AA genotype had seems to be associated for BD-I (p:0.000).

Conclusions: It seems that there is a protective role of COX-2-1195A→G G+ genotype against BD-I (p:0.000). In addition, there was a weak linkage disequilibrium between COX-2-765G→C and COX-2-1195A→G polymorphisms. Our findings suggest that COX-2-1195A→G AA genotype may faciliate the development of BD-I.

MeSH terms

  • Adult
  • Bipolar Disorder / genetics*
  • Cyclooxygenase 2 / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*


  • Cyclooxygenase 2