Renin-positive granulated Goormaghtigh cells. Immunohistochemical and electron-microscopic studies on biopsies from patients with pseudo-Bartter syndrome

Cell Tissue Res. 1989 Jan;255(1):149-53. doi: 10.1007/BF00229076.


It is difficult to distinguish between Goormaghtigh cells (G-cells) and media cells of the glomerular arterioles at the border of the Goormaghtigh cell field. Consequently, it has been unclear whether renin-positive G-cells are normally present and also whether renin-producing cells are recruited from the pool of renin-negative G-cells upon stimulation of the renin-angiotensin system (RAS). In the present study, immunohistochemical and electron-microscopic experiments have been carried out on serially sectioned kidney biopsies from four patients with pseudo-Bartter syndrome. The results strongly suggest that with long-lasting stimulation of the RAS all renin-negative ("secretory resting") G-cells are ultimately converted into renin-producing granular cells.

MeSH terms

  • Adult
  • Aldosterone / metabolism
  • Bartter Syndrome / metabolism*
  • Bartter Syndrome / pathology
  • Biopsy
  • Electrolytes / metabolism
  • Female
  • Glomerular Mesangium / metabolism
  • Glomerular Mesangium / pathology*
  • Humans
  • Hyperaldosteronism / metabolism*
  • Hyperplasia
  • Immunohistochemistry
  • Juxtaglomerular Apparatus / metabolism
  • Juxtaglomerular Apparatus / pathology*
  • Juxtaglomerular Apparatus / ultrastructure
  • Kidney / pathology
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Prostaglandins / metabolism
  • Renin / metabolism*
  • Syndrome


  • Electrolytes
  • Prostaglandins
  • Aldosterone
  • Renin