Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

Abstract

As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / drug effects
  • Brain / metabolism
  • Brain / pathology*
  • Brain / physiopathology
  • Brain Diseases / drug therapy
  • Brain Diseases / genetics
  • Brain Diseases / pathology*
  • Brain Diseases / physiopathology
  • Drug Discovery / methods
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / metabolism
  • Induced Pluripotent Stem Cells / pathology*
  • Mosaicism
  • Neurogenesis*
  • Precision Medicine / methods

Grant support