MRI-Guided Delivery of Viral Vectors

Methods Mol Biol. 2016;1382:217-30. doi: 10.1007/978-1-4939-3271-9_15.

Abstract

Gene therapy has emerged as a potential avenue of treatment for many neurological disorders. Technological advances in imaging techniques allow for the monitoring of real-time infusions into the brain of rodents, nonhuman primates, and humans. Here, we discuss the use of magnetic resonance imaging (MRI) as a tool in the delivery of adeno-associated viral (AAV) particles into brain of nonhuman primates.

Keywords: AAV; Gene therapy; MRI; Nonhuman primates; Preclinical.

MeSH terms

  • Animals
  • Brain / virology*
  • Dependovirus / genetics
  • Genetic Therapy / methods
  • Genetic Vectors / administration & dosage*
  • Macaca fascicularis
  • Macaca mulatta
  • Magnetic Resonance Imaging / instrumentation*
  • Magnetic Resonance Imaging / methods