Neurotrophic Factors and Their Potential Applications in Tissue Regeneration

Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):89-99. doi: 10.1007/s00005-015-0376-4. Epub 2015 Nov 26.


Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. They have been studied as potential drug candidates for treating neurodegenerative diseases. Since their identification, there are more and more evidences to indicate that neurotrophic factors are also expressed in non-neuronal tissues and regulate the survival, anti-inflammation, proliferation and differentiation in these tissues. This mini review summarizes the characteristics of the neurotrophic factors and their potential clinical applications in the regeneration of neuronal and non-neuronal tissues.

Keywords: Neurotrophic factor; Tissue regeneration.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Guided Tissue Regeneration*
  • Humans
  • Nerve Growth Factors / physiology
  • Nerve Growth Factors / therapeutic use*
  • Neurodegenerative Diseases / drug therapy*
  • Neurons / physiology*


  • Anti-Inflammatory Agents
  • Nerve Growth Factors