Autophagy Mediates Tumor Suppression via Cellular Senescence

Trends Cell Biol. 2016 Jan;26(1):1-3. doi: 10.1016/j.tcb.2015.11.001. Epub 2015 Nov 21.

Abstract

Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.

Keywords: ATG7; HRAS; LC3; cytoplasmic chromatin fragments; lamin B1; tumor suppression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Autophagy*
  • Cell Transformation, Neoplastic / genetics
  • Cellular Senescence*
  • Humans
  • Oncogenes