Clinical evaluation of the Heart Check system, a new quantitative measurement of fresh capillary BNP

Biomark Med. 2015;9(12):1323-30. doi: 10.2217/bmm.15.95. Epub 2015 Nov 19.


Aim: We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood.

Patients & methods: One-hundred-and-sixty-three patients with stable chronic heart failure followed at the cardiac rehabilitation were submitted to simultaneous capillary (AHC) and plasma (Abbott architect system) BNP measurements.

Results: Both methods showed a good correlation, although the values diverged when BNP was higher than 2000 pg/ml. Despite a relatively poor precision of AHC, however, both methods showed the same performances to assess patients' dyspnea and equivalent sensitivity, specificity, negative and positive predicting values.

Conclusion: AHC BNP test is a good POC for the management of heart failure despite a relatively poor precision.

Keywords: BNP; capillary whole blood; chronic heart failure; correlation; evaluation; immunoassay; patient dyspnea assessment; point of care; reference method; sensitivity; specificity.

MeSH terms

  • Aged
  • Capillaries / metabolism*
  • Feasibility Studies
  • Female
  • Heart Failure / blood
  • Humans
  • Immunoassay / methods*
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Point-of-Care Systems*
  • ROC Curve
  • Reagent Kits, Diagnostic
  • Reference Standards


  • Reagent Kits, Diagnostic
  • Natriuretic Peptide, Brain