Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis

J Immunol Res. 2015:2015:101879. doi: 10.1155/2015/101879. Epub 2015 Nov 3.


Psoriasis is a chronic skin disease in which genetics play a major role. Although many genome-wide association studies have been performed in psoriasis, knowledge of the age at onset remains limited. Therefore, we analyzed 173 single-nucleotide polymorphisms in genes associated with psoriasis and other autoimmune diseases in patients with moderate-to-severe plaque psoriasis type I (early-onset, <40 years) or type II (late-onset, ≥40 years) and healthy controls. Moreover, we performed a comparison between patients with type I psoriasis and patients with type II psoriasis. Our comparison of a stratified population with type I psoriasis (n = 155) and healthy controls (N = 197) is the first to reveal a relationship between the CLMN, FBXL19, CCL4L, C17orf51, TYK2, IL13, SLC22A4, CDKAL1, and HLA-B/MICA genes. When we compared type I psoriasis with type II psoriasis (N = 36), we found a significant association between age at onset and the genes PSORS6, TNF-α, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1. Moreover, we replicated the association between rs12191877 (HLA-C) and type I psoriasis and between type I and type II psoriasis. Our findings highlight the role of genetics in age of onset of psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alleles
  • Case-Control Studies
  • Female
  • Gene Expression
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • HLA-B27 Antigen / genetics*
  • HLA-B27 Antigen / immunology
  • HLA-C Antigens / genetics*
  • HLA-C Antigens / immunology
  • Haplotypes
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Membrane Proteins / immunology
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Psoriasis / genetics*
  • Psoriasis / immunology
  • Psoriasis / pathology
  • Sequence Analysis, DNA
  • Severity of Illness Index
  • Tumor Necrosis Factor-alpha / genetics*
  • Tumor Necrosis Factor-alpha / immunology


  • CLMN protein, human
  • HLA-B protein, human
  • HLA-B27 Antigen
  • HLA-C Antigens
  • Membrane Proteins
  • Tumor Necrosis Factor-alpha