Application of metabolomics to toxicology of drugs of abuse: A mini review of metabolomics approach to acute and chronic toxicity studies

Kei Zaitsu; Yumi Hayashi; Maiko Kusano; Hitoshi Tsuchihashi; Akira Ishii

doi:10.1016/j.dmpk.2015.10.002

Application of metabolomics to toxicology of drugs of abuse: A mini review of metabolomics approach to acute and chronic toxicity studies

Drug Metab Pharmacokinet. 2016 Feb;31(1):21-26. doi: 10.1016/j.dmpk.2015.10.002. Epub 2015 Nov 2.

Authors

Kei Zaitsu¹, Yumi Hayashi², Maiko Kusano³, Hitoshi Tsuchihashi⁴, Akira Ishii⁵

Affiliations

¹ Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. Electronic address: kzaitsu@med.nagoya-u.ac.jp.
² Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan; Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673, Japan. Electronic address: yhayashi@met.nagoya-u.ac.jp.
³ Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: maiko-k@med.nagoya-u.ac.jp.
⁴ Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: tsuchi@med.nagoya-u.ac.jp.
⁵ Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: akishii@med.nagoya-u.ac.jp.

PMID: 26613805
DOI: 10.1016/j.dmpk.2015.10.002

Abstract

Metabolomics has been widely applied to toxicological fields, especially to elucidate the mechanism of action of toxicity. In this review, metabolomics application with focus on the studies of chronic and acute toxicities of drugs of abuse like stimulants, opioids and the recently-distributed designer drugs will be presented in addition to an outline of basic analytical techniques used in metabolomics. Limitation of metabolomics studies and future perspectives will be also provided.

Keywords: Acute toxicity; Chronic toxicity; Drugs of abuse; Metabolomics; Toxicology.

Publication types

Review

MeSH terms

Animals
Humans
Illicit Drugs / toxicity*
Metabolomics*
Substance-Related Disorders / metabolism*

Substances

Illicit Drugs