MR Imaging Biomarkers in Oncology Clinical Trials

Magn Reson Imaging Clin N Am. 2016 Feb;24(1):11-29. doi: 10.1016/j.mric.2015.08.002.


The authors discuss eight areas of quantitative MR imaging that are currently used (RECIST, DCE-MR imaging, DSC-MR imaging, diffusion MR imaging) in clinical trials or emerging (CEST, elastography, hyperpolarized MR imaging, multiparameter MR imaging) as promising techniques in diagnosing cancer and assessing or predicting response of cancer to therapy. Illustrative applications of the techniques in the clinical setting are summarized before describing the current limitations of the methods.

Keywords: CEST; DCE-MR imaging; DSC-MR imaging; Diffusion; Elastography; Hyperpolarized; Multiparametric.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism*
  • Clinical Trials as Topic
  • Humans
  • Magnetic Resonance Imaging / trends*
  • Magnetic Resonance Spectroscopy / methods*
  • Medical Oncology / trends
  • Molecular Imaging / trends*
  • Neoplasms / diagnosis*
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • Outcome Assessment, Health Care / trends


  • Biomarkers, Tumor