Low antimullerian hormone levels may be associated with cardiovascular risk markers in women with diminished ovarian reserve

Gynecol Endocrinol. 2016;32(4):302-5. doi: 10.3109/09513590.2015.1116065. Epub 2015 Nov 27.


There is growing evidence that diminished ovarian reserve (DOR) may be associated with cardiovascular disease (CVD). The aim of the study was to investigate whether there was any relationship between antimullerian hormone (AMH) and CVD risk markers in the study. Ninety women with DOR and 90 women with normal ovarian reserve (NOR) attending the infertility unit at XXXX, were enrolled in the study. CVD risk markers such as insulin resistance [defined by the homeostasis model assessment ratio (HOMA-IR)], C-reactive protein (CRP), low density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), and triglyceride (TG) were assessed. HOMA-IR, CRP, TG, LDL levels were higher and HDL and AMH were lower among patients with DOR compared with controls (p < 0.05, for all). There were positive associations between low AMH and HOMA-IR, CRP, TG, LDL levels and a negative correlation with HDL (p < 0.05, for all). However, multivariate logistic regression analysis showed that HOMA-IR, CRP, TG and HDL were independent variables that were associated with low AMH. There was a close relationship between low AMH and CVD risk markers in the study. Further studies with larger groups are needed to investigate the nature of this link in these patients.

Keywords: Antimullerian hormone; C-reactive protein; cardiovascular risk; diminished ovarian reserve; dyslipidemia; insulin resistance.

MeSH terms

  • Adult
  • Anti-Mullerian Hormone / blood*
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / blood*
  • Case-Control Studies
  • Female
  • Humans
  • Insulin Resistance
  • Lipids / blood
  • Ovarian Reserve*


  • Lipids
  • Anti-Mullerian Hormone
  • C-Reactive Protein