The Prostate Health Index: Its Utility in Prostate Cancer Detection

Urol Clin North Am. 2016 Feb;43(1):1-6. doi: 10.1016/j.ucl.2015.08.001.


The Prostate Health Index is a Food and Drug Administration-approved blood test combining total, free, and [-2]pro prostate-specific antigen with greater specificity than free and total prostate-specific antigen for clinically significant prostate cancer. This article reviews the evidence on the performance of the Prostate Health Index to predict prostate biopsy outcome, its incorporation into multivariable risk-assessment tools, and its ability to predict prognosis after conservative management or prostate cancer treatment.

Keywords: Detection; Prostate Health Index; Prostate cancer; Screening.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / blood*
  • Humans
  • Male
  • Predictive Value of Tests
  • Prognosis
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / therapy
  • Risk Assessment
  • Sensitivity and Specificity
  • United States
  • United States Food and Drug Administration


  • Biomarkers, Tumor
  • Prostate-Specific Antigen