Chitosan as a starting material for wound healing applications

V Patrulea; V Ostafe; G Borchard; O Jordan

doi:10.1016/j.ejpb.2015.08.004

Chitosan as a starting material for wound healing applications

Eur J Pharm Biopharm. 2015 Nov;97(Pt B):417-26. doi: 10.1016/j.ejpb.2015.08.004.

Authors

V Patrulea¹, V Ostafe², G Borchard³, O Jordan⁴

Affiliations

¹ School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland; West University of Timisoara, Department of Biology-Chemistry, Pestalozzi 16, Timisoara 300115, Romania; West University of Timisoara, Advanced Environmental Research Laboratories, Oituz 4, Timisoara 300086, Romania.
² West University of Timisoara, Department of Biology-Chemistry, Pestalozzi 16, Timisoara 300115, Romania; West University of Timisoara, Advanced Environmental Research Laboratories, Oituz 4, Timisoara 300086, Romania.
³ School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland. Electronic address: gerrit.borchard@unige.ch.
⁴ School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland.

PMID: 26614560
DOI: 10.1016/j.ejpb.2015.08.004

Abstract

Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethyl-chitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,N-trimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

Keywords: Biopolymers; Carboxymethyl chitosan; Chitosan; Chitosan (PubChem CID: 21896651); Chitosan derivatives; Drug delivery; Polyelectrolytes; Skin regeneration; Trimethyl chitosan; Wound dressings; Wound healing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bandages
Chemistry, Pharmaceutical
Chitosan / administration & dosage
Chitosan / analogs & derivatives
Chitosan / pharmacology*
Chitosan / toxicity
Humans
Hydrogels
Wound Healing / drug effects*

Substances

Hydrogels
Chitosan